CareLit Fachartikel

Control of Lineage Commitment in Acute Leukaemia

RF Tirtakusuma, S Bomken, O Heidenreich · Klinische Pädiatrie · 2015 · Heft 07

Dokument
1200308
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
RF Tirtakusuma, S Bomken, O Heidenreich
Ausgabe
Heft 07 / 2015
Seiten
–
Erschienen: 2015-07-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0035-1550247

Zusammenfassung

The regulation of lineage fate and commitment is important for understanding haematological malignancies. We describe a lineage switch from infant acute lymphoblastic leukaemia (ALL) to acute myeloid leukaemia (AML) with identical t(4;11) breakpoints, indicating they came from the same cell of origin. To identify the lineage switch drivers we performed exome and RNA sequencing and used single cell sorting to construct a phylogenetic tree to determine the order of mutational acquisition. Exome seq identified 16 and 98 novel somatic variants with 1 and 9 non-synonymous mutations in the ALL and AML respectively. RN…

Schlagworte

Lineage Mutations Genes Commitment Acute Leukaemia Regulation Switch Exome Sequencing Single Mutated Klinische Pädiatrie