CareLit Fachartikel

Cellular barcoding as a tool to investigate the clonal complexity and evolution of ALL

AK Elder, O Heidenreich, HJ Vormoor · Klinische Pädiatrie · 2015 · Heft 07

Dokument
1200310
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
AK Elder, O Heidenreich, HJ Vormoor
Ausgabe
Heft 07 / 2015
Seiten
–
Erschienen: 2015-07-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0035-1550249

Zusammenfassung

There remains some controversy over the applicability of cancer stem cell models to acute lymphoblastic leukaemia. Recent data suggest that the propagating compartment undergoes a clonal evolution process, leading to the co-existence of several different subclones. We aim to provide a comprehensive picture of the clonal complexity and evolution of patient-derived ALL samples engrafted into mice by individually marking leukaemia cells with heritable genetic markers. We demonstrate that a substantial number of leukaemic cells have the potential to engraft NSG mice and propagate the leukaemia and that clonal comple…

Schlagworte

Clonal Complexity Evolution Leukaemia Different Suggest Cells Engraft Results Cellular Barcoding Investigate Klinische Pädiatrie