A Case of Concordant Twins with Infant ALL and Discordant Clinical Outcome – Part II: highlights on an immunoescape phenotype as a potential mechanism of disease persistence
A Alsadeq, H Fedders, BS Petersen, C Kellner, M Peipp, M Bulduk, T Valerius, R Häsler, J Alten, A Möricke, S Strube, T Wiesel, G Cario, M Schrappe, A Franke, M Stanulla, DM Schewe · Klinische Pädiatrie · 2015 · Heft 07
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Zusammenfassung
Acute lymphoblastic leukemia (ALL) in infants is characterized by a high incidence of translocations involving the MLL gene, and is associated with an unfavorable prognosis. Here we investigate a case of monozygotic twin sisters harboring an MLL-ENL fusion. Both sisters had good treatment response at the end of induction. However, Twin A developed an early relapse and succumbed to the disease, whereas Twin B went into a continuous complete remission. To delineate the reasons behind this discrepancy, xenograft mice bearing diagnostic bone marrow (BM) cells of both sisters were generated and the cells recovered we…
