PAK2 (p21-activated kinase 2) – A Key Node in FLT3 Dependent Signaling in Acute Lymphoblastic Leukemia
I Siekmann, K Dierck, S Prall, M Trochimiuk, V Martens, M Khosh, K Abt, F Beck, I Jeremias, A Sickmann, P Nollau, MA Horstmann · Klinische Pädiatrie · 2015 · Heft 07
Bibliografische Angaben
Zusammenfassung
Signaling is a tightly regulated cellular process. Perturbation of critical signaling pathways has been shown to lead to a variety of diseases including cancer. In acute lymphoblastic leukemia (ALL) a substantial number of molecular aberrations affecting signaling pathways have been identified, such as the BCR-ABL translocation leading to constitutive kinase activity. To decipher kinase-dependent signaling networks in childhood ALL, we analysed the expression profile of receptor tyrosine kinases (RTKs) in primary ALL at the protein level. FLT3 and PDGFRb were selected as growth-promoting receptors in ALL to stud…
