CareLit Fachartikel

Metabolic Infrastructure of Pregnant Women With Trisomy 21 Fetuses; Metabolomic Analysis

Emirhan Nemutlu, Tuba Recber, Emine Aydin, Ece Ozkan, Mert Turgal, Mehmet Alikasifoglu, Sedef Kir, Mehmet Sinan Beksac · Zeitschrift für Geburtshilfe und Neonatologie · 2019 · Heft 05 · S. 297-303

Dokument
1205549
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Jahr
2019
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Geburtshilfe und Neonatologie
Autor:innen
Emirhan Nemutlu, Tuba Recber, Emine Aydin, Ece Ozkan, Mert Turgal, Mehmet Alikasifoglu, Sedef Kir, Mehmet Sinan Beksac
Ausgabe
Heft 05 / 2019
Jahrgang 223
Seiten
297-303
Erschienen: 2019-10-01 00:00:00
ISSN
0948-2393
DOI
10.1055/a-0877-7869

Zusammenfassung

Abstract We aimed to configure impaired/altered metabolomic profiles of pregnant women carrying Down syndrome (DS) fetuses. The study involved 21 and 32 pregnant women with DS and euploid fetuses, respectively, as determined by prenatal screening and diagnosis as part of an antenatal care program. Metabolomic analyses were carried out using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-qTOF-MS) methods. A total of 95 metabolites were identified. GC-MS analysis indicated that levels of 2-hydroxybutyric acid, benzoic acid, nonanoic acid, 3-hy…

Schlagworte

Down syndrome Gas Chromatography-Mass Spectrometry Liquid Chromatography-Mass Spectrometry Metabolomics Chromatography Alanine 3-Hydroxybutyric Acid alpha-Tocopherol Benzoic Acid beta-Alanine Creatinine Diagnosis Creatine Cysteine Citrate Aminoacyl-tRNA