Therapeutic approach of human peritoneal carcinomatosis with Dbait in combination with capnoperitoneum

Aims: Peritoneal carcinomatosis is an unmet medical need. Laparoscopy offers a unique opportunity to control and to steer the operating environment during surgery, by loading carbon dioxide with a therapeutic substance and creating the so-called therapeutic capnoperitoneum. We now treated a human sample of peritoneal carcinomatosis from an endometrial adenocarcinoma ex vivo, just after surgery. Methods: A non-toxic therapeutic agent (Dbait) was aerosolized into a box containing diseased human peritoneum under a pressure of 12mmHg CO2. Dbait (non-coding DNA fragments) acts through jamming DNA damage sensing and s…