Tie2 activation promotes protection and reconstitution of the endothelial glycocalyx in human sepsis

Drost, C

CareLit Fachartikel

Tie2 activation promotes protection and reconstitution of the endothelial glycocalyx in human sepsis

Drost, C. · DIVI, Homburg · 2020 · Heft 8 · S. 14 bis 15

Dokument

204363

CareLit-ID

Jahr

2020

Publikation

PDF

nein

Metadaten

DOI

–

zitierfähig

Bibliografische Angaben

Zeitschrift

DIVI, Homburg

Autor:innen

Drost, C.

Ausgabe

Heft 8 / 2020

Jahrgang 11

Seiten

14 bis 15

Erschienen: 2020-08-03 00:00:00

ISSN

1869-716X

DOI

–

Zusammenfassung

Background: The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis and vessel inflammation. We have previously shown that exogenous Angiopoietin-2 (Angpt-2), an antagonist of the endothelium-stabilizing receptor Tie2 secreted by stressed endothelial cells, induces a rapid loss of the eGC on endothelial cells in vitro. We hypothesized that in human sepsis, eGC breakdown is mediated by Angpt-2.