Use and Abuse of Albumin in Clinical Practice
Soni, N.; Margarson, M. · AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie · 2004 · Heft 12 · S. 76 bis 3
Bibliografische Angaben
Zusammenfassung
Albumin has a molecular weight of about 66 000 and compared with other proteins such as fibrinogen or immunoglobulin it is a relatively small molecule. The molecule is a single polypeptide made up of 585 amino acids with several minor variants in its actual configuration. It carries a strong negative charge. It is synthesised in the polysomes bound to the endoplasmic reticulum of hepatocytes. In a healthy adult it is probable that about 9 - 12 g per day are produced. While only 20 - 30 % of hepatocytes seem to produce albumin at any one time, implying a physiological reserve, there is no storage of albumin in th…
