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Lactate in Sepsis and Trauma - Hindrance or Help?

Sladen, R.N. · AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie · 2004 · Heft 4 · S. 22 bis 4

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Jahr
2004
Publikation
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Bibliografische Angaben

Zeitschrift
AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie
Autor:innen
Sladen, R.N.
Ausgabe
Heft 4 / 2004
Jahrgang 39
Seiten
22 bis 4
Erschienen: 2004-04-28 13:00:00
ISSN
0939-2661
DOI
10.1055/s-1999-10736-5

Zusammenfassung

Lactic acid, formed by the reduction of pyruvate in the Embden-Meyerhof pathway, is normally converted back to pyruvate prior to its entry into the oxygen-dependent citrate cycle. In the presence of hypoxemia or shock (which may be simply defined as inadequate tissue perfusion), aerobic glycolysis is impaired and lactate and hydrogen ions accumulate. This results in acidosis, impaired mitochondrial energy production, disturbed ionic homeostasis across cell membranes, and reduced functional capacity of tissue cells [1]. The impact of shock on individual organs depends on their functional activity, basal metabolic…

Schlagworte

SEPSIS TRANSFUSION TRANSPORT REPERFUSION LITERATUR AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie