Gut microbiome and serum metabolome patterns distinguish major and minor responders to a structured weight-loss program: A step towards personalized treatment for obese individuals
Seethaler, B.; Nguyen, N.K.; Basrai, M.; Delzenne, N.M.; Walter, J.; Cani, P.D.; Bischoff, S.C. · Aktuelle Ernährungsmedizin · 2024 · Heft 3 · S. 1 bis 1
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Zusammenfassung
Background: The effectiveness of weight loss programs is highly individualized, with some participants achieving rapid and long-term weight reduction while others do not. Our objective was to identify metabolic and gut microbiome-related patterns associated with weight loss, which can be used for personalized treatment approaches. Methods: We assessed data from 50 obese individuals (BMI 42±7 kg/m2) who participated in a one-year multidisciplinary weight loss program (Optifast®52, Nestlé Health Science). The program consisted of two main phases: First, an initial 6-month phase (‘6M’) where the participants follo…
