CareLit Fachartikel
Vitamin D deficient diet deteriorates gut barrier function by reducing α-defensins in the ileum of C57BL6J mice
Petersen, P.P.; Filipe, R.L.; Bischoff, S.C. · Aktuelle Ernährungsmedizin · 2023 · Heft 3 · S. 1 bis 1
Dokument
327742
CareLit-ID
Jahr
2023
Publikation
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ja
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Zusammenfassung
Introduction The hormone vitamin D (VD) is formed from 7-dehydrocholesterol in the skin by UV radiation. After conversion in the kidney to its active form calcitriol, VD can act on gene expression by binding to the nuclear vitamin D receptor (VDR) [1]. Besides its role for a healthy bone metabolism, VD is also known to be involved in immunomodulation and gut barrier functionality [2]. However, the underlying mechanisms through which VD affects the intestinal barrier remain unclear. Material and Methods To examine the impact of a VD deficient diet on the functionality and integrity of the intestinal barrier, 24 f…
Schlagworte
Gesundheit
Pflege
Diet
Defensins
Calcitriol
Germany
After
Aktuelle Ernährungsmedizin
