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Adipocyte-derived factors induce insulin secretion, glucokinase gene transcription and β-cell proliferation through activation of Wnt-Signaling

Schinner, S.; Papewalis, C.; Kocaoglu, F.; Schott, M.; Vidal-Puig, A.; Bornstein, S.R.; Scherbaum, W.A. · Aktuelle Ernährungsmedizin · 2006 · Heft 5 · S. 1 bis 1

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328125
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2006
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Bibliografische Angaben

Zeitschrift
Aktuelle Ernährungsmedizin
Autor:innen
Schinner, S.; Papewalis, C.; Kocaoglu, F.; Schott, M.; Vidal-Puig, A.; Bornstein, S.R.; Scherbaum, W.A.
Ausgabe
Heft 5 / 2006
Jahrgang 19
Seiten
1 bis 1
Erschienen: 2006-09-28 13:00:00
ISSN
0341-0501
DOI
10.1055/s-2006-954486

Zusammenfassung

Summary: Obesity is associated with insulin resistance, β-cell hyperplasia and hyperinsulinemia. Adipocytes secrete Wnt-signaling molecules. Wnts regulate cell-cycle progression and insulin secetion. However, it has not been investigated whether adipocytes regulate β-cell proliferation and insulin secretion through the Wnt-signaling pathway. Therefore, we investigated the effect of adipocyte-secretory products on Wnt-signaling in β-cells. Treatment with human FCCM increased the transcription of a Wnt reporter-gene (TOPFLASH) in Ins-1 cells (241% as compared to untreated controls, p

Schlagworte

Gesundheit Pflege Adipocytes Adipozyten Obesity Aktuelle Ernährungsmedizin