Metabolic phenotyping of an overweight mouse line originated from ethyl-nitroso-urea (ENU) mutagenesis
Ehrhardt, N.; Rozman, J.; Schwarz, A.E.; Rathkolb, B.; Fuchs, H.; Gailus-Durner, V.; de Angelis, M.H.; Heldmaier, G.; Klingenspor, M. · Aktuelle Ernährungsmedizin · 2006 · Heft 5 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
The Metabolic Laboratory of the German Mouse Clinic performs a comprehensive analysis of energy balance in mouse mutants. It is based on the conflation of different calorimetrical systems for investigation of disturbances in body weight regulation, metabolism and body composition. We investigated an overweight mouse mutant line which originated from the Munich ENU Mutagenesis project. At the age of 18 weeks body weight (BW) of control males (n=8) was 35.4±0.1g (means±sem) and of females (n=7) 26.6±0.9g. The mean BW of mutant males (n=6) was 45.6±0.3g and of females (n=6) 35.6±0.5g. The daily metabolized energy p…
