Evolutionary Perspective of MC4R
Hughes, D.A.; Hinney, A.; Wermter, A.K.; Hebebrand, J.; Biebermann, H.; Stoneking, M. · Aktuelle Ernährungsmedizin · 2006 · Heft 5 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Introduction and Aim: Obesity is fast becoming a major global health problem, and identifying the alleles which contribute to this problem is of great importance. The melanocortin-4 receptor gene (MC4R) is a key protein in the regulation of adiposity, and many different null alleles have been identified at this locus, causing up to 6% of the obesity cases in the world. In this study we present a population genetics and evolutionary perspective of this locus. Specifically we investigate natural variation at this locus for over 50 world populations and an analysis of the evolutionary history of the protein coding…
