The ATGL gene is associated with free fatty acids, triglycerides and type 2 diabetes
Heid, I.M.; Vollmert, C.; Schoenborn, V.; Lingenhel, A.; Adams, T.D.; Hopkins, P.N.; Illig, T.; Zimmermann, R.; Zechner, R.; Hunt, S.C.; Kronenberg, F. · Aktuelle Ernährungsmedizin · 2006 · Heft 5 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Adipose triglyceride lipase (ATGL) was recently described to predominantly perform the initial step in triglyceride hydrolysis and therefore seems to play a pivotal role in the lipolytic catabolism of stored fat in adipose tissue. In the first study investigating genetic variations within the ATGL gene in humans, twelve polymorphisms identified via sequencing and database search were studied in 2434 individuals of European ancestry from Utah. These polymorphisms and their haplotypes were analyzed in subjects not taking diabetic medication for association with plasma free fatty acids (FFA) as primary analysis, as…
