Ablation of cholesterol transporter ABCG1 in mice reduces adipose cell size and corrects diet-induced insulin resistance
Buchmann, J.; Meyer, C.; Neschen, S.; Schmolz, K.; Augustin, R.; Kluge, R.; Eulenberg, K.; Wehr, R.; Dohrmann, C.; Joost, H.G.; Schürmann, A. · Aktuelle Ernährungsmedizin · 2006 · Heft 5 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Introduction: The aim of our study was to identify obesity genes as targets for the treatment of the metabolic syndrome. We performed two genome wide screenings, a random mutagenesis in Drosophila melanogaster and a QTL analysis in a polygenic obesity mouse model, the New Zealand obese (NZO) mouse. By comparing the results of these two screenings we identified several putative candidates. Methods: EP-element-bearing Drosophila melanogaster flies were generated and screened for their triglyceride content. Via this technique we identified 200 candidate genes which alter fat accumulation in the flies. One of the id…
