Estimation of the in vivo metabolic rate of adipose tissue in obese mice
Keipert, S.; Wessels, J.; Klingenspor, M.; Rozman, J. · Aktuelle Ernährungsmedizin · 2006 · Heft 5 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Adipose tissue is generally regarded as a metabolically rather inactive tissue, but its contribution to total basal metabolic rate in mammals should not be neglected [1]. The obese db/db mouse offers the unique opportunity to estimate the in vivo metabolic rate of adipose tissue, as massive fat storage occurs without significant accretion of lean mass. We investigated the effect of the db allele (Leprdb), which conveys a loss of leptin receptor (Lepr) signalling, on the allometric relationships between basal metabolic rate, body mass and lean mass in mice of the C57BL/KsOlaHsd background. Mice homozygous for the…