Gastric inhibitory polypeptide receptors are presented in human subcutaneous adipose tissue: Effects of central obesity and weight loss
Rudovich, N.N.; Kaiser, S.; Engeli, S.; Feldpausch, M.; Gorzelniak, K.; Heintze, U.; Janke, J.; Luft, F.C.; Sharma, A.M.; Pfeiffer, A.F.H. · Aktuelle Ernährungsmedizin · 2004 · Heft 5 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Aims: Gastric inhibitory polypeptide (GIP), a duodenal hormone, released postprandially in response to feeding, producing a glucose-dependent stimulation of insulin secretion. Recent study in rodents suggested that GIP directly links between overnutrition to obesity. Despite evidence for GIP effects on fat metabolism in humans, GIP-receptor (GIP-R) has not been identified in fat tissues. To identify GIP-R in subcutaneous adipose tissue in human and to test the hypothesis that gene expression of this gene can be influenced by different metabolical parameters and weight loss. Methods and Materials: GIP-R gene expr…
