Vitamin C Stability in Total Parenteral Nutrition: Critical Influence of „All-In-One“ Bag Properties

Aims: Recent development of multilayered (ML) bags has enabled to greatly diminish the vitamin C oxidation that occurs between total parenteral nutrition (TPN) admixture compounding and patient's infusion. However, the extent of the gas-barrier property of ML bags depends on the combination of plastic films used. This study aimed to assess vitamin C stability in three different ML bags following variations in temperature and storage time. Methods: Oxygen infiltration and vitamin C stability were assessed in three different ML bags of identical wall thickness, using gas chromatography and iodometric assay or high…