Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects
van Harmelen, V.; Röhrig, K.; Hauner, H. · Aktuelle Ernährungsmedizin · 2003 · Heft 5 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Upper body obesity is characterized by an expansion of visceral adipose tissue and associated with an increased susceptibility for diabetes and cardiovascular disease. To get a better understanding of the regulation of body fat distribution, adipocyte development was compared between the omental and subcutaneous adipose tissue region in 29 obese subjects. Therefore, the proliferation and differentiation capacity in primary cultures of adipose tissue-derived stromal cells were studied. Differentiation of preadipocytes was assessed by morphological criteria and determination of glycerol-3-phosphate dehydrogenase a…