Oral N-3 PUFAs Attenuate the Neuro-Endocrine Response to Endotoxin in Healthy Subjects
Michaeli, B.; Tappy, L.; Revelly, J.P.; Cayeux, C.; Soguel, L.; Berger, M.M.; Chiolero, R. · Aktuelle Ernährungsmedizin · 2004 · Heft 2 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Introduction: The inflammatory syndrome is a frequent condition in critically ill patients. The sequence and interaction of proinflammatory mediators is complex and not yet completely understood. N-3 PUFAs have various non-energetic effects and are supposed to reduce the production of prostaglandines and leukotrienes. Single intravenous bolus injection of endotoxin (LPS) is a model generating a sustained inflammatory response (systemic, metabolic, endocrine changes) in healthy men. By this model we aimed at assessing the immuno-regulating potential of n3-PUFAs in 15 healthy volunteers, randomized to receive (n=7…
