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Drug-Food Interactions induced by proton-pump inhibitors: decreased bioavailability of transition metals due to pH-dependent worsening of aquo-complexes' solubility

Jenzer, H.; Marty, I.; Ruch, L.; Scheidegger-Balmer, F.; Sadeghi, L. · Aktuelle Ernährungsmedizin · 2016 · Heft 3 · S. 1 bis 1

Dokument
328534
CareLit-ID
Jahr
2016
Publikation
PDF
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DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Ernährungsmedizin
Autor:innen
Jenzer, H.; Marty, I.; Ruch, L.; Scheidegger-Balmer, F.; Sadeghi, L.
Ausgabe
Heft 3 / 2016
Jahrgang 19
Seiten
1 bis 1
Erschienen: 2016-06-08 13:00:00
ISSN
0341-0501
DOI
10.1055/s-0036-1583868

Zusammenfassung

Purpose: Malabsorption of micronutrients is an adverse effect of proton pump inhibitors (PPIs). This work elucidates worsening solubility of metal aquo-complexes when changing gastrointestinal pH from 2.0 (men) or 2.5 (women) to permanently more than 4.0. Methods: A simple model of solubility of trace metal ions at GI tube-like pH was validated. Mixtures of 0.5% FeCl3 or CuSO4 with or w/o 1% ascorbic acid (to stabilize reduced forms) were screened in vitro using turbidimetric UV/Vis absorption spectrometry. Results: Fe (+III, ferric) and Cu (+II, cupric) states have a high charge density, small ionic radius (e.g…

Schlagworte

Gesundheit Pflege Absorption Ascorbic Acid Work Aktuelle Ernährungsmedizin