Degeneration of the neuromuscular junction as a cause for sarcopenia measured by C-terminal Agrin Fragment
Drey, M.; Bauer, J.; Sieber, C.; Dahinden, P.; Fariello, R.; Vrijbloed, J. · Aktuelle Ernährungsmedizin · 2012 · Heft 3 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Introduction: Sarcopenia has to be considered as a great burden for the affected individual and for society as well. Among the different etiologic factors for sarcopenia, the degeneration of the neuromuscular junction (NMJ) plays an important role. The balance between the pro-synaptic agent agrin and its counterpart neurotrypsin is essential for a structurally intact and well functioning neuromuscular junction. Excessive cleavage of the proteoglycane agrin by the enzyme neurotrypsin into a C-terminal Agrin Fragment (CAF) leads to a functional deterioration at the endplate and thus consecutively promote sarcopeni…
