CareLit Fachartikel
Evidence for an intracellular mechanism contributing to cholesterol lowering activity of phytosterols
Brauner, R.; Johannes, C.; Lorenz, R. · Aktuelle Ernährungsmedizin · 2009 · Heft 3 · S. 1 bis 1
Dokument
328855
CareLit-ID
Jahr
2009
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background: Phytosterols are enriched in functional food products to lower plasma LDL cholesterol by reducing fractional intestinal cholesterol absorption. Beside micellar intraluminal effects, intracellular mechanisms may be operative but direct evidence is still lacking. The ABC sterol transporters ABCG5/8 involved in phytosterol re-excretion and ABCA1 involved in cellular cholesterol export are expressed in the human enterocyte and carry a Liver X Receptor (LXR) response element. Ligands for LXR are side chain hydroxylated cholesterol metabolites. We hypothesized that phytosterols might in analogy to choleste…
Schlagworte
Gesundheit
Pflege
Cholesterol
After
2-Hydroxypropyl-beta-cyclodextrin
Caco-2 Cells
Absorption
Aktuelle Ernährungsmedizin
