Albumin synthesis rates are not responsive to hyperglycemic hyperinsulinemia in postoperative subjects
Kuppinger, D.; Braun, S.; Rittler, P.; Demmelmair, H.; Koletzko, B.; Jauch, K.; Hartl, W. · Aktuelle Ernährungsmedizin · 2009 · Heft 3 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Background: Insulin effectively controls albumin gene expression, albumin mRNA content, and albumin synthesis in vitro and in various experimental models. The current study was undertaken to determine the effects of a physiologic hyperinsulinemia on albumin synthesis in postoperative patients in whom plasma albumin concentrations are decreased and in whom albumin synthetic rates are insufficient to compensate the postoperative albumin deficit. Methods: Studies were performed in postabsorptive patients after major abdominal operations. Mass spectrometry techniques (capillary gas chromatography/combustion isotope…
