CareLit Fachartikel
TGF-ß promotes alcohol dependent liver damage by favouring its oxidative stress producing metabolism
Ciuclan, L.; Godoy, P.; Breitkopf, K.; Singer, M.; Dooley, S. · Aktuelle Ernährungsmedizin · 2006 · Heft 3 · S. 1 bis 1
Dokument
328939
CareLit-ID
Jahr
2006
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background: Fibrogenesis in alcoholic liver disease involves cytokines, acetaldehyde, oxidative stress and complex interactions between liver cells. Major hepatotoxic effects during chronic alcohol consumption result from activating the microsomal oxidizing system (MEOS), which generates free radicals, lipid peroxidation, and depletion of mitochondrial reduced glutathione. TGF-β is induced in livers of patients with alcoholic cirrhosis and recognised as master profibrogenic cytokine. However, direct participation of TGF-β signaling in adverse action of alcohol was not identified yet. Aim: To show a crosstalk bet…
Schlagworte
Gesundheit
Pflege
After
Acetaldehyde
Aldehyde Dehydrogenase
Cytochrome
Cytokines
Aldehyde
Cytokine
Aktuelle Ernährungsmedizin
