Effects of human ghrelin and the peptide analogues, BIM-28131 and BIM-28125, on body weight, food intake and body composition in a rat model of heart failure
Palus, S.; Springer, J.; Akashi, Y.; Datta, R.; Halem, H.; Dong, J.; Culler, M.; Anker, S. · Aktuelle Ernährungsmedizin · 2006 · Heft 3 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
A serious complication of chronic heart failure is cardiac cachexia (CC) with a prevalence of 10–15% in CHF patients. The complex metabolic changes entail a catabolic/anabolic imbalance which leads to body wasting and poor prognosis. There is currently no therapeutic option for CC. Ghrelin, the natural ligand for the growth hormone secretagogue (GHS) receptor, has been demonstrated to induce food intake and is suggested to enhance cardiac function. Methods: Human ghrelin and two peptide analogues, BIM-28125 and BIM-28131, were tested at 50 or 500nmole/kg/d versus placebo in a CHF-model induced by acute myocardia…
