Formation of 5-nitro-gamma-tocopherol in smokers and non-smokers after mixed tocopherol supplementation
Sundl, I.; Meinitzer, A.; Maritschnegg, M.; Roob, J.M.; Tiran, B.; Verdino, T.; Knes, O.; Winklhofer-Roob, B.M. · Aktuelle Ernährungsmedizin · 2007 · Heft 3 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Aims: Smokers are exposed to reactive nitrogen species (RNS) which are present at high amounts in cigarette smoke. Because of an unsubstituted position on the chromanol ring, gamma-tocopherol (GT) but not alpha-tocopherol traps certain RNS with the consequent formation of 5-Nitro-GT (NGT) (1). The aim of this randomized, double-blind placebo-controlled study was to compare NGT concentrations and NGT:GT ratios before and after supplementation with AT and mixed tocopherols (MT) containing 14% AT and 60% GT, and possible determinants of NGT in smokers (S) versus non-smokers (NS). Methods: Healthy male S (n=34) and…
