CareLit Fachartikel
TGFbeta dependent polyamine depletion is associated with cell growth inhibitory effects of isothiocyanate sulforaphane in colon cancer cells
Ecker, B.; Jochem, C.; Kampan, W.; Loitsch, S.; Stein, J.; Ulrich, S. · Aktuelle Ernährungsmedizin · 2008 · Heft 3 · S. 1 bis 1
Dokument
329185
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction: Sulforaphane (SFN), a naturally occurring isothiocyanate present in cruciferous vegetables, is an attractive agent due to its potent anticancer effects. SFN was shown to suppress the proliferation of various cancer cells in vitro and in vivo, whereas the underlying molecular mechanisms remain largely unknown. Previous studies could demonstrate that modulation of polyamine metabolism provides a chemopreventive strategy of different phytochemicals. Thus, the objective of this study was to elucidate a possible regulation of ornithine decarboxylase (ODC), the key enzyme of polyamine biosynthesis, by SF…
Schlagworte
Gesundheit
Pflege
Cells
Polyamine
Growth
Sulforaphane
Caco-2
Ornithine
Decarboxylase
Culture
Sw620
Dependent
Effects
Isothiocyanate
Aktuelle Ernährungsmedizin
