Economic modeling of risk-adapted screen-and-treat strategies in women at high-risk for breast or ovarian cancer

Background: Approximately 28% of women with an increased incidence of breast or ovarian cancer in their families have a genetic mutation in cancer genes BRCA1 or BRCA2. While several preventive strategies are available, the cost-effectiveness of genetic testing in these women is still unknown. Objective: The aim of this modeling study was to evaluate the cost-effectiveness of genetic testing in women with a high familial risk followed by different preventive strategies (surveillance, mastectomy, oophorectomy, or both mastectomy and oophorectomy) compared to women non-informed about their mutation status. The ana…