High circulating levels of adrenomedullin are associated with metabolic syndrome, insulin resistance and low cardiorespiratory fitness in BRCA1 and BRCA2 mutation carriers
Lammert, J.; Grill, S.; Yahiaoui-Doktor, M.; Basrai, M.; Struck, J.; Hartmann, O.; Bischoff, S.; Halle, M.; Kiechle, M. · Aktuelle Ernährungsmedizin · 2020 · Heft 3 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Background Risk factors for cardiovascular disease (CVD) and breast cancer overlap substantially. Identification of the underlying mechanisms associated with this co-occurrence is of great public health importance. Adrenomedullin (AM) is a widely expressed peptide with vasodilator and natriuretic properties. Previous studies showed a link between high AM levels and worse prognosis in patients with myocardial infarction and heart failure, indicating a crucial role in the pathophysiology of CVD. Elevated AM levels are associated with arterial hypertension, obesity and smoking. Moreover, 80 % of breast cancers expr…
