ER Negatively Regulates Insulin Signalling In Vivo
Foryst-Ludwig, A.; Clemenz, M.; Hohmann, S.; Hartge, M.; Sprang, C.; Frost, N.; Krikov, M.; Gustafsson, J.; Unger, T.; Kintscher, U. · Aktuelle Ernährungsmedizin · 2007 · Heft 5 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Estrogen receptors (ERs) belong to the family of nuclear receptors and have been suggested to play an important role in the underlying molecular mechanisms of gender differences in metabolic disorders. We recently demonstrated that female βERKO mice, fed a high fat diet (HFD, 59% kcal from fat) for 12 weeks, show an improvement of whole body insulin sensitivity and glucose tolerance in comparison to wild-type (WT) HFD-fed control mice. However, the underlying mechanism of ERβ-mediated regulation of insulin- and glucose metabolism has not been clarified. Here we investigated triglyceride (TG) load and insulin sig…
