CareLit Fachartikel
D Vitamer Synthesis Of Basal And Differentiated Keratinocytes Following UVB Irradiation
Portius, D.; Santoro, M.; Stangl, G.I. · Aktuelle Ernährungsmedizin · 2025 · Heft 2 · S. 1 bis 1
Dokument
349625
CareLit-ID
Jahr
2025
Publikation
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Metadaten
DOI
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Zusammenfassung
Introduction: Vitamin D (VitD) is classically activated via hepatic 25-hydroxylation and renal 1α-hydroxylation, leading to the production of bioactive 1,25(OH)₂D₃. Keratinocytes possess the entire enzymatic machinery for local VitD activation. Although it is known that keratinocytes are able to produce VitD3 from 7-dehydrocholesterol via UVB light exposure and hydroxylated vitamin D metabolites, their role in contributing to an increase in plasma 25(OH)D levels is rather unkown. In addition, there is scarce information on whether basal keratinocytes differ from differentiated keratinocytes in UVB-exposed synthe…
Schlagworte
Vitamer-Synthese
Keratinozyten
UVB-Bestrahlung
basale Keratinozyten
differenzierte Keratinozyten
Hautzellen
Keratinocytes
Ultraviolet Rays
Vitamins
Skin
Cell Differentiation
Aktuelle Ernährungsmedizin
