Core GRADE for evidence syntheses

GRADE is a globally recognized approach for assessing the certainty of evidence (also: quality or certainty of evidence) and formulating recommendations in systematic reviews, guidelines and other evidence syntheses. GRADE (Grading of Recommendations Assessment, Development and Evaluation) was introduced approximately 20 years ago by an international working group led by Canadian physician Gordon Guyatt, one of the pioneers of evidence-based practice [1]. GRADE has evolved continuously over time and has now reached a high level of complexity. In the context of the strengths and weaknesses of the established GRAD…