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Genetic Sum Score of Risk Alleles Associated with Type 2 Diabetes Interacts with Socioeconomic Status in Heinz Nixdorf Recall Study

Frank, M.; Dragano, N.; Forstner, A.; Moebus, S.; Jöckel, K.; Schmidt, B. · Das Gesundheitswesen · 2017 · Heft 8/09 · S. 1 bis 1

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574110
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Jahr
2017
Publikation
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Bibliografische Angaben

Zeitschrift
Das Gesundheitswesen
Autor:innen
Frank, M.; Dragano, N.; Forstner, A.; Moebus, S.; Jöckel, K.; Schmidt, B.
Ausgabe
Heft 8/09 / 2017
Jahrgang 79
Seiten
1 bis 1
Erschienen: 2017-09-01 13:00:00
ISSN
0941-3790
DOI
10.1055/s-0037-1605855

Zusammenfassung

Introduction: Studies exploring the influence of the socioeconomic status (SES) on the expression of disease-related genetic variants are sparse. The aim of this study was to investigate whether a sum score of genetic risk alleles related to Type 2 Diabetes Mellitus (T2D) interacts with indicators of SES in a population-based cohort. Methods: A genetic risk score (GRS) was calculated using 73 T2D-associated single nucleotide polymorphisms, selected from the latest genome-wide association meta-analysis, which were genotyped in 4, 518 participants (age 45 – 74 years) of the Heinz Nixdorf Recall Study. SES and T2D…

Schlagworte

Association Population Alleles Diabetes Mellitus Allele Das Gesundheitswesen