Enterolactone levels and postmenopausal breast cancer survival: Assessment of mediation by inflammatory markers
Jaskulski, S.; Jung, A.; Johnson, T.; Thöne, K.; Sookthai, D.; Chang-Claude, J. · Das Gesundheitswesen · 2017 · Heft 8/09 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Introduction: In a meta-analysis we previously found evidence for protective effects of higher lignan exposure (dietary estimates or biomarkers) on both all-cause mortality (ACM) and breast cancer (BC)-specific mortality (BCSM) for postmenopausal BC patients. To identify hormone-independent mechanisms relating lignans to BC prognosis, we investigated for the first time whether and to what extent the association between enterolactone (ENL), the major lignan metabolite, and postmenopausal BC prognosis is mediated by inflammatory biomarkers. Methods: Data from a German patient cohort study of 2, 115 BC patients (MA…
