Vaccination in childhood and the risk of childhood cancer – a systematic review and meta-analyses

Several epidemiological studies investigated potential associations between vaccination in childhood and childhood cancer. However, results were inconsistent and a meta-analysis on this topic is lacking. Systematic searches of the PubMed and Web of Science databases on childhood cancer and vaccination were conducted. We identified 4, 163 studies, of which 52 studies fulfilled the inclusion criteria for this review. Pooled odds ratios (OR) were calculated using random effects models if three or more studies for a specific research question in this field were available. Overall, we observed 75 effect estimates for…