CareLit Fachartikel

Role of Polygenic Risk Score for Coronary Artery Disease and its Traditional Risk Factors with Progression of Coronary Artery Calcification

Pechlivanis, S.; Lehmann, N.; Erbel, R.; Jöckel, K.; Nöthen, M.; Moebus, S. · Das Gesundheitswesen · 2017 · Heft 8/09 · S. 1 bis 1

Dokument
574436
CareLit-ID
Jahr
2017
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Das Gesundheitswesen
Autor:innen
Pechlivanis, S.; Lehmann, N.; Erbel, R.; Jöckel, K.; Nöthen, M.; Moebus, S.
Ausgabe
Heft 8/09 / 2017
Jahrgang 79
Seiten
1 bis 1
Erschienen: 2017-09-01 13:00:00
ISSN
0941-3790
DOI
10.1055/s-0037-1605856

Zusammenfassung

Introduction: Atherosclerosis is the primary cause of coronary artery disease (CAD). Several studies have examined the association of traditional CAD risk factors (CRF) for the progression of coronary artery calcification (CAC). Our study describes the genetic architecture of progression of CAC by assessing the combined effect of the risk alleles associated with CAD and its traditional risk factors. Methods: We included 2786 participants (54. 4% female) of the Heinz Nixdorf Recall Study with CAC measured at baseline (BL) and 5-year follow-up. We constructed unweighted polygenic risk score (PRS) for CAD, type 2 d…

Schlagworte

Blood Pressure Association Alleles Allele Blood Atherosclerosis Architecture Cholesterol After Atherosklerose Das Gesundheitswesen