Mediating Factors of the Association between Physical Activity and Colon Cancer: Lessons from the EPIC Cohort
Aleksandrova, K.; Jenab, M.; Leitzmann, M.; Bueno-de-Mesquita, B.; Kaaks, R.; Riboli, E.; Boeing, H. · Das Gesundheitswesen · 2017 · Heft 8/09 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
Background: Accumulating evidence has emerged suggesting an association between physical activity and lower risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We quantified potential mediation effect of body fatness and biomarkers of various biologically plausible pathways on the association between physical activity and colon cancer. Methods: We conducted a nested case-control study in a cohort of 519, 978 men and women. A total of 713 incident colon cancer cases were matched using risk-set sampling to 713 controls on age, sex, study center, fasting status, and hormonal…
