CareLit Fachartikel
The effects of sclerostin antibody plus parathyroid hormone (1–34) on bone formation in ovariectomized rats
Wu, J.; Cai, X.; Qin, X.; Liu, Y. · Zeitschrift für Gerontologie und Geriatrie · 2017 · Heft 5 · S. 550 bis 556
Dokument
578654
CareLit-ID
Jahr
2017
Publikation
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DOI
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Zusammenfassung
Previous studies have demonstrated the effects of sclerostin antibody (Scl-Ab) and parathyroid hormone (1-34, PTH) on healing in osteoporosis; however, reports about the combined effects of Scl-Ab plus PTH on osteoporosis are limited. This study was designed to investigate the impact of combined treatment with Scl-Ab and PTH on osteoporosis healing in ovariectomized (OVX) rats. After bilateral ovariectomy, 12 weeks were allowed to pass for the establishment of standard conditions for osteoporosis in animal models. The rats then randomly received a vehicle (control), Scl-Ab (25 mg/kg body weight, twice weekly), P…
Schlagworte
Sclerostin-Antikörper
Parathormon
Osteoporose
ovariektomierte Ratten
Knochenbildung
Therapie
Biomechanik
Histologie
Mikrotomographie
Sclerostin Antibodies
Parathyroid Hormone
Osteoporosis
Ovariectomy
Bone Density
Bone Remodeling
Zeitschrift für Gerontologie und Geriatrie
