Update der S3-Leitlinie Sepsis 2025 – was ist neu?

The recently revised German Sepsis Guideline 2025 reflects an increasing integration of personalised therapy principles. This trend is observed in key recommendations relating to early recognition, anti-infective therapy, hemodynamic support, and organ-protective strategies. Early detection should be performed using validated screening instruments. Additionally, antibiotic therapy must be adapted to the individual patient, with administration ideally starting within one hour in cases of septic shock and no later than three hours in sepsis without shock. The guideline further emphasises timely diagnostics and hem…