CareLit Fachartikel

Genetics of inherited platelet disorders

Gothwal, M.; Sandrock-Lang, K.; Zieger, B. · Zeitschrift für Orthopädie und Unfallchirurgie · 2014 · Heft 02 · S. 133 bis 141

Dokument
611161
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Orthopädie und Unfallchirurgie
Autor:innen
Gothwal, M.; Sandrock-Lang, K.; Zieger, B.
Ausgabe
Heft 02 / 2014
Jahrgang 34
Seiten
133 bis 141
Erschienen: 2014-01-01 00:00:00
ISSN
0720-9355;2567-5761
DOI
10.5482/hamo-13-09-0049

Zusammenfassung

SummaryThe current review describes inherited platelet disorders, illustrates their clinical phenotype and molecular genetic defects. Platelets are the key molecules mediating haemostasis via adhesion, activation and clot formation at the site of injury. The inherited platelet disorders can be classified according to their platelet defects: receptor/cytoskeleton defects, secretion disorder, and signal transduction defect.Patients with inherited thrombocytopathia present with mucous membrane bleedings (epistaxis, gingival bleeding) and may present with serious life threatening bleedings following surgery or traum…

Schlagworte

Inherited Platelet Disorders Defects Their Molecular Genetic Present Bleedings Summarythe Current Review Zeitschrift für Orthopädie und Unfallchirurgie