CareLit Fachartikel

Resistance to activated protein C, the FV: Q506 allele, and venous thrombosis

Hillarp, A.; Rosen, S.; Zöller, B.; Dahlbäck, B. · Zeitschrift für Orthopädie und Unfallchirurgie · 1998 · Heft 01 · S. 1 bis 10

Dokument
611557
CareLit-ID
Jahr
1998
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Orthopädie und Unfallchirurgie
Autor:innen
Hillarp, A.; Rosen, S.; Zöller, B.; Dahlbäck, B.
Ausgabe
Heft 01 / 1998
Jahrgang 18
Seiten
1 bis 10
Erschienen: 1998-01-01 00:00:00
ISSN
0720-9355;2567-5761
DOI
10.1055/s-0038-1655322

Zusammenfassung

SummaryVitamin K-dependent protein C is an important regulator of blood coagulation. After its activation on the endothelial cell surface by thrombin bound to thrombomodulin, it cleaves and inactivates procoagulant cofactors Va and Villa, protein S and intact factor V working as cofactors. Until recently, genetic defects of protein C or protein S were, together with antithrombin III deficiency, the established major causes of familial venous thromboembolism, but they were found in fewer than 5-10% of patients with thrombosis. In 1993, inherited resistance to activated protein C (APC) was described as a major ris…

Schlagworte

Antithrombin III Allele Antithrombin III Deficiency Blood Coagulation Population Arginine Blood After Zeitschrift für Orthopädie und Unfallchirurgie