CareLit Fachartikel

A Vicious Circle of Clonal Haematopoiesis of Indeterminate Potential and Cardiovascular Disease

Ehlert, C.-A.; Hilgendorf, I. · Zeitschrift für Orthopädie und Unfallchirurgie · 2021 · Heft 06 · S. 443 bis 446

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611878
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Jahr
2021
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Orthopädie und Unfallchirurgie
Autor:innen
Ehlert, C.-A.; Hilgendorf, I.
Ausgabe
Heft 06 / 2021
Jahrgang 41
Seiten
443 bis 446
Erschienen: 2021-12-01 00:00:00
ISSN
0720-9355;2567-5761
DOI
10.1055/a-1576-4059

Zusammenfassung

AbstractClonal haematopoiesis of indeterminate potential (CHIP) represents a recently identified overlap between cancer and cardiovascular disease (CVD). CHIP develops as a result of certain acquired somatic mutations that predispose to leukaemia, but clinically even more prevalent, associate with increased risk for CVD and CVD-related death. Experimental studies suggest a causal role for CHIP aggravating inflammatory processes in CVD, and recent epidemiologic and genetic studies indicate that classical CVD risk factors may increase the risk of acquiring CHIP driver mutations, thus fuelling a vicious circle. The…

Schlagworte

Studies Vicious Circle Potential Between Mutations Experimental Inflammatory Recent Which Haematopoiesis Indeterminate Zeitschrift für Orthopädie und Unfallchirurgie