CareLit Fachartikel

The principles of PK-tailored prophylaxis

Chehadeh, H.-E.; Reininger, A.-J. · Zeitschrift für Orthopädie und Unfallchirurgie · 2013 · Heft S 01 · S. S32-S35

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612047
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Jahr
2013
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Orthopädie und Unfallchirurgie
Autor:innen
Chehadeh, H.-E.; Reininger, A.-J.
Ausgabe
Heft S 01 / 2013
Jahrgang 33
Seiten
S32-S35
Erschienen: 2013-01-01 00:00:00
ISSN
0720-9355;2567-5761
DOI
10.1055/s-0037-1619800

Zusammenfassung

SummaryWhile prophylaxis with factor VIII (FVIII) is considered the first choice therapy for patients with severe haemophilia A the optimal prophylaxis regimen is still under scientific debate. A recent study demonstrated efficacy and safety of a PK-tailored prophylaxis regimen with rFVIII (ADVATE) aimed to maintain FVIII trough levels of ≥1% (19). The annual bleed rate (ABR) could be significantly reduced compared to the previous on-demand treatment period (p < 0.0001) and bodily pain, a health-related quality of life dimension of the SF-36v1 questionnaire also significantly improved (p = 0.0007). Thus PKtailor…

Schlagworte

Prophylaxis Fviii Pk-Tailored Trough Considered Patients Regimen Advate Levels Bleed Significantly Summarywhile Zeitschrift für Orthopädie und Unfallchirurgie