Biomarkers for arterial and venous thrombotic disorders
Mannhalter, C. · Zeitschrift für Orthopädie und Unfallchirurgie · 2014 · Heft 02 · S. 115 bis 132
Bibliografische Angaben
Zusammenfassung
SummaryThe haemostatic system maintains the blood in a fluid state, but allows rapid clot formation at sites of vascular injury to prevent excessive bleeding. Unbalances within the haemostatic system can lead to thrombosis. Inspite of successful research our understanding of the disease pathogenesis is still incomplete. There is great hope that genetic, genomic, and epigenetic discoveries will enhance the diagnostic capability, and improve the treatment options. During the preceding 20 years, the identification of polymorphisms and the elucidation of their role in arterial and venous thromboses became an importa…