Antiphospholipid Antibodies in a General Obstetric Population: Clinical Impact on Pregnancy Outcome and Relationship with the M2 Haplotype in the Annexin A5 (ANXA5) Gene
Villani, M.; Colaizzo, D.; Martinelli, P.; Cappucci, F.; Fischetti, L.; Maruotti, G.-M.; Intrieri, M.; Greco, L.; Chinni, E.; Tiscia, G.-L.; Margaglione, M.; Grandone, E. · Zeitschrift für Orthopädie und Unfallchirurgie · 2019 · Heft 02 · S. 203 bis 207
Bibliografische Angaben
Zusammenfassung
AbstractAntiphospholipid (aPL) antibodies are recognised risk factors for adverse obstetric outcomes. Recently, carriers of the M2 haplotype in the Annexin A5 gene have been shown to have a higher susceptibility to develop aPL antibodies. In a general obstetric population, we prospectively evaluated the possible relationship between: (1) aPL antibodies and M2 haplotype; and (2) aPL antibodies and/or M2 haplotype and obstetric outcomes. From a cohort of 3,097 consecutive pregnant women, 1,286 samples were analysed for the presence of both anti-cardiolipin and anti-human β2-glycoprotein I antibodies; samples with…
