The impact and management of acquired platelet dysfunction
Rahman, M.-M.; Seidel, H.; Scharf, R.-E. · Zeitschrift für Orthopädie und Unfallchirurgie · 2011 · Heft 01 · S. 28 bis 40
Bibliografische Angaben
Zusammenfassung
SummaryPlatelet function can be abnormally increased, as in association with acute vascular events, or defective, as in a variety of clinical settings. Acquired platelet dysfunction may occur at any age and range in severity from mild to life-threatening haemorrhages. Diagnostic work-up of platelet disorders requires meticulous evaluation of medical history, specifically of any drugs interfering with platelet function, careful clinical examination and a staged laboratory protocol to assess the underlying platelet defect(s). To identify hyperactive platelets ex vivo, costly procedures may be required using flow c…