Ex vivo/In vitro Interaction between ASA, Clopidogrel and GPIIb/IIIa-Inhibitors
Kirchmaier, C.-M.; Westrup, D.; Graff, J.; Mahnel, R.; Breddin, H.-K.; Harder, S.; Klinkhardt, U. · Zeitschrift für Orthopädie und Unfallchirurgie · 1999 · Heft 03 · S. 112 bis 114
Bibliografische Angaben
Zusammenfassung
SummaryWe report on an in vivo interaction study between aspirin (ASA) and Clopidogrel in healthy male volunteers and on an in-vitro interaction of abciximab and the peptidomimetic GPIIb/IIIa-inhibitor SR121566A with blood from subjects of the in vivo-study. Ten healthy male volunteers were randomly assigned to two groups (N = 5). Group 1 started with ASA and group 2 with Clopidogrel. From day 4 to 8 subjects of both groups received combined treatment with ASA and Clopidogrel. Blood from volunteers was spiked with abciximab or SR121566A. Inhibitory effects of ASA and Clopidogrel on collagen- or ADP-induced plate…
