Enhanced thrombin generation in plasma of severe thrombocytopenic patients due to rFVIIa
Novak, M.; Hiden, M.; Rehak, T.; Rosenkranz, A.; Zebisch, A.; Sill, H.; Klaschka, S.; Muntean, W. · Zeitschrift für Orthopädie und Unfallchirurgie · 2008 · Heft S 01 · S. S77-S80
Bibliografische Angaben
Zusammenfassung
SummaryRFVIIa-enhanced thrombin generation has been shown to be dependent on platelets. In previous work we have shown that addition of monocytes and rFVIIa to microparticle free plasma causes a distinct thrombin generation. The aim of our study has been to examine whether there is enough surface provided by microparticles in thrombocytopenic plasma to allow an effect of rFVIIa. Patients, methods: Thrombin generation was measured in platelet rich plasma (PRP) and microparticle free plasma (MFP) of thrombocytopenic haemato-oncological patients with and without addition of rVIIa by means of calibrated automated th…
